人 PCSK6 (NM_138322) cDNA克隆

基本信息

Accession: NM_138322
基因名称: PCSK6
基因别名: SPC4; PACE4
基因描述: Homo sapiens proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1464 (查看编码区序列)
翻译后氨基酸长度: 487 (查看氨基酸序列)
Transcript Variant: This variant (3), also known as PACE4B and PACE4.1, uses an alternate splice site and one alternate exon in the coding region and 3' UTR respectively, and lacks several downstream exons when compared to variant 1. These differences cause a frameshift and thus isoform c has a distinct C-terminus compared to isoform a. This encoded isoform is thought to be catalytically inactive. The preproprotein is annotated since the cleavage sites are maintained as in isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G153578 人 PCSK6 (NM_138322) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PCSK6 (NM_002570) cDNA克隆 transcript variant 1
人 PCSK6 (NM_138319) cDNA克隆 transcript variant 2
人 PCSK6 (NM_138322) cDNA克隆 transcript variant 3
人 PCSK6 (NM_138324) cDNA克隆 transcript variant 4
人 PCSK6 (NM_138323) cDNA克隆 transcript variant 5
人 PCSK6 (NM_138325) cDNA克隆 transcript variant 6

基因简介

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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