人 FLT1 (NM_001159920) cDNA克隆

基本信息

Accession: NM_001159920
基因名称: FLT1
基因别名: FLT; FLT-1; VEGFR1; VEGFR-1
基因描述: Homo sapiens fms-related tyrosine kinase 1 (FLT1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2064 (查看编码区序列)
翻译后氨基酸长度: 687 (查看氨基酸序列)
Transcript Variant: This variant (2), also known as sFlt1 or sVEGFR-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded soluble protein (isoform 2) has a shorter, distinct C-terminus and lacks the transmembrane and cytoplasmic regions of isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G140315 人 FLT1 (NM_001159920) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 FLT1 (NM_002019) cDNA克隆 transcript variant 1
人 FLT1 (NM_001159920) cDNA克隆 transcript variant 2
人 FLT1 (NM_001160030) cDNA克隆 transcript variant 3
人 FLT1 (NM_001160031) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

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