人 MARCH2 (NM_001005416) cDNA克隆

基本信息

Accession: NM_001005416
基因名称: MARCH2
基因别名: RNF172; HSPC240; MARCH-II
基因描述: Homo sapiens membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase (MARCH2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 531 (查看编码区序列)
翻译后氨基酸长度: 176 (查看氨基酸序列)
Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G125261 人 MARCH2 (NM_001005416) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MARCH2 (NM_016496) cDNA克隆 transcript variant 1
人 MARCH2 (NM_001005415) cDNA克隆 transcript variant 2
人 MARCH2 (NM_001005416) cDNA克隆 transcript variant 3

基因简介

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

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