人 PIF1 (NM_001286497) cDNA克隆

Accession: NM_001286497
基因名称: PIF1
基因别名: PIF; C15orf20
基因描述: Homo sapiens PIF1 5'-to-3' DNA helicase (PIF1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2124 (查看编码区序列)
翻译后氨基酸长度: 707 (查看氨基酸序列)
Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and contains an alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b, also known as beta) has a distinct C-terminus and is longer than isoform a. This isoform localizes to the mitochondria (PMID: 17827721).
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G165581 人 PIF1 (NM_001286497) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]