Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In mice, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Two pseudogenes exist for this gene, one on chromosome 10 and one on chromosome 17. [provided by RefSeq, Jul 2008]
小鼠 Gpx4 (NM_008162) cDNA克隆
| Accession: | NM_008162 |
|---|---|
| 基因名称: | Gpx4 |
| 基因别名: | PHGPx; snGPx; mtPHGPx; 1700027O09Rik |
| 基因描述: | Mus musculus glutathione peroxidase 4 (Gpx4), transcript variant 2, mRNA. |
| 种属: | Mouse |
| CDS区长度: | 594 (查看编码区序列) |
| 翻译后氨基酸长度: | 197 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) represents the shorter transcript and encodes the shorter isoform (2). A similar transcript in rat generates long and short forms of the encoded protein through alternative transcription initiation sites, the long form contains a mitochondrial transit peptide and localizes to the mitochondrion. The rat short form lacks a mitochondrial transit peptide and is present in the cytoplasm. |
| 小鼠 Gpx4 (NM_001037741) cDNA克隆 | transcript variant 1 |
| 小鼠 Gpx4 (NM_008162) cDNA克隆 | transcript variant 2 |
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