人 PRLR (NM_001204317) cDNA克隆

基本信息

Accession: NM_001204317
基因名称: PRLR
基因别名: HPRL; MFAB; hPRLrI
基因描述: Homo sapiens prolactin receptor (PRLR), transcript variant 4, mRNA.
种属: Human
CDS区长度: 867 (查看编码区序列)
翻译后氨基酸长度: 288 (查看氨基酸序列)
Transcript Variant: This variant (4) is missing an exon at the 3' end, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (4, also known as SF1b for short form 1b) with a distinct C-terminus compared to isoform 1. This isoform is functional with a strong dominant-negative effect on the function of isoform 1 (PMID:12580759).

订购信息

产品编号 产品名称 载体 规格 价格
G155679 人 PRLR (NM_001204317) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PRLR (NM_000949) cDNA克隆 transcript variant 1
人 PRLR (NM_001204315) cDNA克隆 transcript variant 2
人 PRLR (NM_001204316) cDNA克隆 transcript variant 3
人 PRLR (NM_001204317) cDNA克隆 transcript variant 4
人 PRLR (NM_001204318) cDNA克隆 transcript variant 5
人 PRLR (NM_001204314) cDNA克隆 transcript variant 6

基因简介

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

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