人 OTUD5 (NM_001136159) cDNA克隆

基本信息

Accession: NM_001136159
基因名称: OTUD5
基因别名: DUBA
基因描述: Homo sapiens OTU domain containing 5 (OTUD5), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1050 (查看编码区序列)
翻译后氨基酸长度: 349 (查看氨基酸序列)
Transcript Variant: This variant (4) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform c) has a shorter N-terminus, compared to isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G155347 人 OTUD5 (NM_001136159) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 OTUD5 (NM_017602) cDNA克隆 transcript variant 1
人 OTUD5 (NM_001136157) cDNA克隆 transcript variant 2
人 OTUD5 (NM_001136158) cDNA克隆 transcript variant 3
人 OTUD5 (NM_001136159) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

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