人 OTUD5 (NM_001136158) cDNA克隆

基本信息

Accession: NM_001136158
基因名称: OTUD5
基因别名: DUBA
基因描述: Homo sapiens OTU domain containing 5 (OTUD5), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1701 (查看编码区序列)
翻译后氨基酸长度: 566 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 3' UTR and lacks an in-frame portion of an internal coding exon, compared to variant 1, resulting in a shorter protein compared to isoform a. Variants 2 and 3 encode the same isoform (b).

订购信息

产品编号 产品名称 载体 规格 价格
G155346 人 OTUD5 (NM_001136158) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 OTUD5 (NM_017602) cDNA克隆 transcript variant 1
人 OTUD5 (NM_001136157) cDNA克隆 transcript variant 2
人 OTUD5 (NM_001136158) cDNA克隆 transcript variant 3
人 OTUD5 (NM_001136159) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

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