人 PDE4A (NM_001243121) cDNA克隆

基本信息

Accession: NM_001243121
基因名称: PDE4A
基因别名: PDE4; DPDE2; PDE46
基因描述: Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 5, mRNA.
种属: Human
CDS区长度: 2595 (查看编码区序列)
翻译后氨基酸长度: 864 (查看氨基酸序列)
Transcript Variant: This variant (5) contains additional exons at the 5' end compared to variant 1. It encodes a shorter isoform (5, also known as PDE4A8) with a distinct N-terminus compared to isoform 1. This isoform is expressed predominantly in skeletal muscle and brain, a pattern that differs from that of other isoforms, and thus may have a specific function in regulating cAMP levels in human skeletal muscle and brain (PMID:18095939).

订购信息

产品编号 产品名称 载体 规格 价格
G153960 人 PDE4A (NM_001243121) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PDE4A (NM_001111307) cDNA克隆 transcript variant 1
人 PDE4A (NM_001111308) cDNA克隆 transcript variant 2
人 PDE4A (NM_001111309) cDNA克隆 transcript variant 3
人 PDE4A (NM_006202) cDNA克隆 transcript variant 4
人 PDE4A (NM_001243121) cDNA克隆 transcript variant 5

基因简介

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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