小鼠 Txnrd1 (NM_001042513) cDNA克隆

基本信息

Accession: NM_001042513
基因名称: Txnrd1
基因别名: TR; TR1; TrxR1
基因描述: Mus musculus thioredoxin reductase 1 (Txnrd1), transcript variant 2, mRNA.
种属: Mouse
CDS区长度: 1500 (查看编码区序列)
翻译后氨基酸长度: 499 (查看氨基酸序列)
Transcript Variant: This variant (2) has different 5' non-coding exons, and is missing an alternate 5' coding exon compared to transcript variant 1. This results in a shorter isoform (2) with a different N-terminus compared to isoform 1. Transcript variants 2, 3 and 4 encode the same isoform.

订购信息

产品编号 产品名称 载体 规格 价格
G153599 小鼠 Txnrd1 (NM_001042513) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

小鼠 Txnrd1 (NM_001042523) cDNA克隆 transcript variant 1
小鼠 Txnrd1 (NM_001042513) cDNA克隆 transcript variant 2
小鼠 Txnrd1 (NM_015762) cDNA克隆 transcript variant 3
小鼠 Txnrd1 (NM_001042514) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the family of pyridine nucleotide-disulfide oxidoreductases. This protein is a flavoenzyme, which uses NADPH for reduction of thioredoxins as well as other protein and nonprotein substrates, and plays a role in protection against oxidative stress. It contains a selenocysteine (Sec) residue, which is essential for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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