人 BBC3 (NM_014417) cDNA克隆

基本信息

Accession: NM_014417
基因名称: BBC3
基因别名: JFY1; PUMA; JFY-1
基因描述: Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 4, mRNA.
种属: Human
CDS区长度: 582 (查看编码区序列)
翻译后氨基酸长度: 193 (查看氨基酸序列)
Transcript Variant: This variant (4) has alternate exon structure at its 5' end and it thus differs in the 5' UTR and 5' coding region, compared to variant 2. The encoded isoform (4, also known as PUMA-alpha) has a distinct N-terminus and is longer than isoform 2. Isoform 4 also includes the C-terminal BH3 domain and can localize to the mitochondria.

订购信息

产品编号 产品名称 载体 规格 价格
G145015 人 BBC3 (NM_014417) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 BBC3 (NM_001127240) cDNA克隆 transcript variant 1
人 BBC3 (NM_001127241) cDNA克隆 transcript variant 2
人 BBC3 (NM_001127242) cDNA克隆 transcript variant 3
人 BBC3 (NM_014417) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

相关产品