人 BBC3 (NM_001127242) cDNA克隆

基本信息

Accession: NM_001127242
基因名称: BBC3
基因别名: JFY1; PUMA; JFY-1
基因描述: Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 3, mRNA.
种属: Human
CDS区长度: 306 (查看编码区序列)
翻译后氨基酸长度: 101 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks two exons spanning the 5' and central coding regions, resulting in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (3, also known as PUMA-delta) has the same N-terminus but is otherwise distinct and shorter, compared to isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G145014 人 BBC3 (NM_001127242) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 BBC3 (NM_001127240) cDNA克隆 transcript variant 1
人 BBC3 (NM_001127241) cDNA克隆 transcript variant 2
人 BBC3 (NM_001127242) cDNA克隆 transcript variant 3
人 BBC3 (NM_014417) cDNA克隆 transcript variant 4

基因简介

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

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