小鼠 Rnaseh1 (NM_001286865) cDNA克隆

基本信息

Accession: NM_001286865
基因名称: Rnaseh1
基因描述: Mus musculus ribonuclease H1 (Rnaseh1), transcript variant 1, mRNA.
种属: Mouse
CDS区长度: 780 (查看编码区序列)
翻译后氨基酸长度: 259 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes two isoforms due to the use of alternative translation initiation codons. The longer isoform (1) is derived from the upstream AUG start codon, while the shorter isoform (2) is derived from the downstream AUG start codon. This RefSeq represents the shorter isoform (2), which is a nuclear protein (see details in PMID: 20823270).

订购信息

产品编号 产品名称 载体 规格 价格
G135838 小鼠 Rnaseh1 (NM_001286865) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

小鼠 Rnaseh1 (NM_001286865) cDNA克隆 transcript variant 1
小鼠 Rnaseh1 (NM_011275) cDNA克隆 transcript variant 1

基因简介

This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which encodes 7aa in mouse. An alternately spliced transcript variant has been found which is a candidate for nonsense-mediated mRNA decay (NMD). [provided by RefSeq, Nov 2013]

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