人 CDKN1C (NM_001122631) cDNA克隆

基本信息

Accession: NM_001122631
基因名称: CDKN1C
基因别名: BWS; WBS; p57; BWCR; KIP2; p57Kip2
基因描述: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA.
种属: Human
CDS区长度: 918 (查看编码区序列)
翻译后氨基酸长度: 305 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction in the 3' UTR compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.

订购信息

产品编号 产品名称 载体 规格 价格
G126610 人 CDKN1C (NM_001122631) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 CDKN1C (NM_000076) cDNA克隆 transcript variant 1
人 CDKN1C (NM_001122630) cDNA克隆 transcript variant 2
人 CDKN1C (NM_001122631) cDNA克隆 transcript variant 3

基因简介

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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