人 PTK6 (NM_001256358) cDNA克隆

Accession: NM_001256358
基因名称: PTK6
基因别名: BRK
基因描述: Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 2, mRNA.
种属: Human
CDS区长度: 405 (查看编码区序列)
翻译后氨基酸长度: 134 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. This variant is also known as lambdaM5 and Alt-PTK6.
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G125138 人 PTK6 (NM_001256358) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]