人 PTK2B (NM_173176) cDNA克隆

Accession: NM_173176
基因名称: PTK2B
基因别名: PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
基因描述: Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 3, mRNA.
种属: Human
CDS区长度: 3030 (查看编码区序列)
翻译后氨基酸长度: 1009 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
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G116319 人 PTK2B (NM_173176) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]