人 MKL1 (NM_001282662) cDNA克隆

基本信息

Accession: NM_001282662
基因名称: MKL1
基因别名: MAL; BSAC; MRTF-A
基因描述: Homo sapiens megakaryoblastic leukemia (translocation) 1 (MKL1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 2397 (查看编码区序列)
翻译后氨基酸长度: 798 (查看氨基酸序列)
Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G124853 人 MKL1 (NM_001282662) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MKL1 (NM_020831) cDNA克隆 transcript variant 1
人 MKL1 (NM_001282660) cDNA克隆 transcript variant 2
人 MKL1 (NM_001282661) cDNA克隆 transcript variant 3
人 MKL1 (NM_001282662) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

相关产品