人 MKL1 (NM_001282661) cDNA克隆

基本信息

Accession: NM_001282661
基因名称: MKL1
基因别名: MAL; BSAC; MRTF-A
基因描述: Homo sapiens megakaryoblastic leukemia (translocation) 1 (MKL1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2646 (查看编码区序列)
翻译后氨基酸长度: 881 (查看氨基酸序列)
Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G124852 人 MKL1 (NM_001282661) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MKL1 (NM_020831) cDNA克隆 transcript variant 1
人 MKL1 (NM_001282660) cDNA克隆 transcript variant 2
人 MKL1 (NM_001282661) cDNA克隆 transcript variant 3
人 MKL1 (NM_001282662) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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