人 ROBO1 (NM_001145845) cDNA克隆

基本信息

Accession: NM_001145845
基因名称: ROBO1
基因别名: SAX3; DUTT1
基因描述: Homo sapiens roundabout, axon guidance receptor, homolog 1 (Drosophila) (ROBO1), transcript variant 4, mRNA.
种属: Human
CDS区长度: 4656 (查看编码区序列)
翻译后氨基酸长度: 1551 (查看氨基酸序列)
Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and differs at three internal regions, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.

订购信息

产品编号 产品名称 载体 规格 价格
G124745 人 ROBO1 (NM_001145845) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ROBO1 (NM_002941) cDNA克隆 transcript variant 1
人 ROBO1 (NM_133631) cDNA克隆 transcript variant 2
人 ROBO1 (NM_001145844) cDNA克隆 transcript variant 3
人 ROBO1 (NM_001145845) cDNA克隆 transcript variant 4

基因简介

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

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