人 TLR4 (NM_003266) cDNA克隆

基本信息

Accession: NM_003266
基因名称: TLR4
基因别名: TOLL; CD284; TLR-4; ARMD10
基因描述: Homo sapiens toll-like receptor 4 (TLR4), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2400 (查看编码区序列)
翻译后氨基酸长度: 799 (查看氨基酸序列)
Transcript Variant: This variant (3) contains an additional internal exon compared to transcript variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which results in an isoform (C) with a shorter N-terminus compared to isoform A.

订购信息

产品编号 产品名称 载体 规格 价格
G122702 人 TLR4 (NM_003266) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TLR4 (NM_138554) cDNA克隆 transcript variant 1
人 TLR4 (NM_003266) cDNA克隆 transcript variant 3
人 TLR4 (NM_138557) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

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