人 RASSF1 (NM_007182) cDNA克隆

基本信息

Accession: NM_007182
基因名称: RASSF1
基因别名: 123F2; RDA32; NORE2A; RASSF1A; REH3P21
基因描述: Homo sapiens Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant A, mRNA.
种属: Human
CDS区长度: 1023 (查看编码区序列)
翻译后氨基酸长度: 340 (查看氨基酸序列)
Transcript Variant: This variant (A) lacks an in-frame coding segment compared to variant D, resulting an isoform (A) that lacks an internal region, as compared to isoform D.

订购信息

产品编号 产品名称 载体 规格 价格
G121853 人 RASSF1 (NM_007182) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 RASSF1 (NM_007182) cDNA克隆 transcript variant A
人 RASSF1 (NM_170712) cDNA克隆 transcript variant B
人 RASSF1 (NM_170713) cDNA克隆 transcript variant C
人 RASSF1 (NM_170714) cDNA克隆 transcript variant D
人 RASSF1 (NM_001206957) cDNA克隆 transcript variant H

基因简介

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

相关产品