人 BCL11A (NM_018014) cDNA克隆

基本信息

Accession: NM_018014
基因名称: BCL11A
基因别名: EVI9; CTIP1; ZNF856; HBFQTL5; BCL11A-L; BCL11A-S; BCL11a-M; BCL11A-XL
基因描述: Homo sapiens B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2322 (查看编码区序列)
翻译后氨基酸长度: 773 (查看氨基酸序列)
Transcript Variant: This variant (2) is also known as B-cell lymphoma/leukaemia 11A long form (BCL11A-L). It has a different 3' end coding and UTR region when compared to variant 1, and thus encodes an isoform (2) that contains a different and shorter C-terminus, as compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G117841 人 BCL11A (NM_018014) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 BCL11A (NM_022893) cDNA克隆 transcript variant 1
人 BCL11A (NM_018014) cDNA克隆 transcript variant 2
人 BCL11A (NM_138559) cDNA克隆 transcript variant 3

基因简介

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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