人 BCL10 (NM_003921) cDNA克隆

Accession: NM_003921
基因名称: BCL10
基因别名: CLAP; mE10; CIPER; c-E10; CARMEN
基因描述: Homo sapiens B-cell CLL/lymphoma 10 (BCL10), mRNA.
种属: Human
CDS区长度: 702 (查看编码区序列)
翻译后氨基酸长度: 233 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G117148 人 BCL10 (NM_003921) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]