人 NAE1 (NM_001018159) cDNA克隆

Accession: NM_001018159
基因名称: NAE1
基因别名: HPP1; ula-1; APPBP1; A-116A10.1
基因描述: Homo sapiens NEDD8 activating enzyme E1 subunit 1 (NAE1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1587 (查看编码区序列)
翻译后氨基酸长度: 528 (查看氨基酸序列)
Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
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G104071 人 NAE1 (NM_001018159) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]