人 PPP1R8 (NM_002713) cDNA克隆

基本信息

Accession: NM_002713
基因名称: PPP1R8
基因别名: ARD1; ARD-1; NIPP1; NIPP-1; PRO2047
基因描述: Homo sapiens protein phosphatase 1, regulatory subunit 8 (PPP1R8), transcript variant 3, mRNA.
种属: Human
CDS区长度: 384 (查看编码区序列)
翻译后氨基酸长度: 127 (查看氨基酸序列)
Transcript Variant: This variant (3) encodes the shortest isoform (gamma, also called ARD-1). It has its first exon longer at the 3' end and lacks an internal exon as compared to that of transcript variant 1. The gamma isoform uses a different translation start site and is N-terminally truncated as compared to isoform alpha encoded by variant 1. Isoform gamma contains ribonuclease activity.

订购信息

产品编号 产品名称 载体 规格 价格
G103440 人 PPP1R8 (NM_002713) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PPP1R8 (NM_014110) cDNA克隆 transcript variant 1
人 PPP1R8 (NM_138558) cDNA克隆 transcript variant 2
人 PPP1R8 (NM_002713) cDNA克隆 transcript variant 3

基因简介

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

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