人 DPH3 (NM_001047434) cDNA克隆

Accession: NM_001047434
基因名称: DPH3
基因别名: DESR1; DPH3A; KTI11; ZCSL2; DELGIP; DELGIP1
基因描述: Homo sapiens diphthamide biosynthesis 3 (DPH3), transcript variant 2, mRNA.
种属: Human
CDS区长度: 174 (查看编码区序列)
翻译后氨基酸长度: 57 (查看氨基酸序列)
Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
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G102736 人 DPH3 (NM_001047434) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]