人 ITGB1 (NM_033668) cDNA克隆

基本信息

Accession: NM_033668
基因名称: ITGB1
基因别名: CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
基因描述: Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1D, mRNA.
种属: Human
CDS区长度: 2406 (查看编码区序列)
翻译后氨基酸长度: 801 (查看氨基酸序列)
Transcript Variant: This variant (1D) includes an alternate exon, known as exon D, which results in a frameshift in the 3' coding region, compared to variant 1A. The resulting isoform (1D) has a distinct and longer C-terminus, compared to isoform 1A. This variant lacks full-length transcript support; its exon combination is predicted based on partial human transcript alignments, homologous transcript alignments including full-length cow mRNA BC114107.1, and data in the literature, including PMIDs 7544298, 7545396, 8567725 and 11779688, which consider this to be a functionally significant variant. This variant lacks a 5' UTR due to alternative splicing choices upstream of the CDS, and uncertainty about which alternative promoter is used.

订购信息

产品编号 产品名称 载体 规格 价格
G102562 人 ITGB1 (NM_033668) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 ITGB1 (NM_002211) cDNA克隆 transcript variant 1A
人 ITGB1 (NM_033668) cDNA克隆 transcript variant 1D
人 ITGB1 (NM_133376) cDNA克隆 transcript variant 1E

基因简介

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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