人 SGK1 (NM_001143676) cDNA克隆

基本信息

Accession: NM_001143676
基因名称: SGK1
基因别名: SGK
基因描述: Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 1581 (查看编码区序列)
翻译后氨基酸长度: 526 (查看氨基酸序列)
Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.

订购信息

产品编号 产品名称 载体 规格 价格
G101870 人 SGK1 (NM_001143676) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 SGK1 (NM_005627) cDNA克隆 transcript variant 1
人 SGK1 (NM_001143676) cDNA克隆 transcript variant 2
人 SGK1 (NM_001143677) cDNA克隆 transcript variant 3
人 SGK1 (NM_001143678) cDNA克隆 transcript variant 4

基因简介

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

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