人 EP300 (NM_001429) cDNA克隆

Accession: NM_001429
基因名称: EP300
基因别名: p300; KAT3B; RSTS2
基因描述: Homo sapiens E1A binding protein p300 (EP300), mRNA.
种属: Human
CDS区长度: 7245 (查看编码区序列)
翻译后氨基酸长度: 2414 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G170785 人 EP300 (NM_001429) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]