人 MAP4K4 (NM_001242560) cDNA克隆

基本信息

Accession: NM_001242560
基因名称: MAP4K4
基因别名: HGK; NIK; MEKKK4; FLH21957
基因描述: Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), transcript variant 5, mRNA.
种属: Human
CDS区长度: 3708 (查看编码区序列)
翻译后氨基酸长度: 1235 (查看氨基酸序列)
Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.

订购信息

产品编号 产品名称 载体 规格 价格
G168142 人 MAP4K4 (NM_001242560) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MAP4K4 (NM_004834) cDNA克隆 transcript variant 1
人 MAP4K4 (NM_145686) cDNA克隆 transcript variant 2
人 MAP4K4 (NM_145687) cDNA克隆 transcript variant 3
人 MAP4K4 (NM_001242559) cDNA克隆 transcript variant 4
人 MAP4K4 (NM_001242560) cDNA克隆 transcript variant 5

基因简介

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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