人 TNFRSF11A (NM_001270949) cDNA克隆

基本信息

Accession: NM_001270949
基因名称: TNFRSF11A
基因别名: FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
基因描述: Homo sapiens tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A), transcript variant 2, mRNA.
种属: Human
CDS区长度: 792 (查看编码区序列)
翻译后氨基酸长度: 263 (查看氨基酸序列)
Transcript Variant: This variant (2, also known as delta9) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G166957 人 TNFRSF11A (NM_001270949) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 TNFRSF11A (NM_003839) cDNA克隆 transcript variant 1
人 TNFRSF11A (NM_001270949) cDNA克隆 transcript variant 2
人 TNFRSF11A (NM_001270950) cDNA克隆 transcript variant 3
人 TNFRSF11A (NM_001270951) cDNA克隆 transcript variant 4
人 TNFRSF11A (NM_001278268) cDNA克隆 transcript variant 5

基因简介

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

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