人 PDE5A (NM_033437) cDNA克隆

基本信息

Accession: NM_033437
基因名称: PDE5A
基因别名: CN5A; PDE5; CGB-PDE
基因描述: Homo sapiens phosphodiesterase 5A, cGMP-specific (PDE5A), transcript variant 3, mRNA.
种属: Human
CDS区长度: 2472 (查看编码区序列)
翻译后氨基酸长度: 823 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3, also known as PDE5A3) is shorter at the N-terminus, compared to isoform 1. There are no publicly available full-length transcripts supporting this variant; it is represented based on full-length cloning by RT-PCR in PMID:10679255.

订购信息

产品编号 产品名称 载体 规格 价格
G166917 人 PDE5A (NM_033437) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PDE5A (NM_001083) cDNA克隆 transcript variant 1
人 PDE5A (NM_033430) cDNA克隆 transcript variant 2
人 PDE5A (NM_033437) cDNA克隆 transcript variant 3

基因简介

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

相关产品