人 PICALM (NM_001206947) cDNA克隆

基本信息

Accession: NM_001206947
基因名称: PICALM
基因别名: LAP; CALM; CLTH
基因描述: Homo sapiens phosphatidylinositol binding clathrin assembly protein (PICALM), transcript variant 4, mRNA.
种属: Human
CDS区长度: 1656 (查看编码区序列)
翻译后氨基酸长度: 551 (查看氨基酸序列)
Transcript Variant: This variant (4) has an alternate 5' exon, resulting in a downstream AUG start codon, and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G166122 人 PICALM (NM_001206947) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PICALM (NM_007166) cDNA克隆 transcript variant 1
人 PICALM (NM_001008660) cDNA克隆 transcript variant 2
人 PICALM (NM_001206946) cDNA克隆 transcript variant 3
人 PICALM (NM_001206947) cDNA克隆 transcript variant 4

基因简介

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

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