人 EHMT1 (NM_001145527) cDNA克隆

Accession: NM_001145527
基因名称: EHMT1
基因别名: GLP; GLP1; KMT1D; FP13812; EUHMTASE1; Eu-HMTase1; bA188C12.1; RP11-188C12.1
基因描述: Homo sapiens euchromatic histone-lysine N-methyltransferase 1 (EHMT1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2427 (查看编码区序列)
翻译后氨基酸长度: 808 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
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G165482 人 EHMT1 (NM_001145527) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]