人 NFE4 (NM_001085386) cDNA克隆

Accession: NM_001085386
基因名称: NFE4
基因别名: NF-E4
基因描述: Homo sapiens nuclear factor, erythroid 4 (NFE4), mRNA.
种属: Human
CDS区长度: 540 (查看编码区序列)
翻译后氨基酸长度: 179 (查看氨基酸序列)
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G156743 人 NFE4 (NM_001085386) cDNA克隆 pDONR223 2ug质粒 点击询价

The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq, Jul 2008]