人 PTGIS (NM_000961) cDNA克隆

Accession: NM_000961
基因名称: PTGIS
基因别名: CYP8; PGIS; PTGI; CYP8A1
基因描述: Homo sapiens prostaglandin I2 (prostacyclin) synthase (PTGIS), mRNA.
种属: Human
CDS区长度: 1503 (查看编码区序列)
翻译后氨基酸长度: 500 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G156441 人 PTGIS (NM_000961) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]