人 PDE4B (NM_001037340) cDNA克隆

基本信息

Accession: NM_001037340
基因名称: PDE4B
基因别名: DPDE4; PDE4B5; PDEIVB
基因描述: Homo sapiens phosphodiesterase 4B, cAMP-specific (PDE4B), transcript variant c, mRNA.
种属: Human
CDS区长度: 2166 (查看编码区序列)
翻译后氨基酸长度: 721 (查看氨基酸序列)
Transcript Variant: This variant (c) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (3, also referred to as PDE4B3) has a shorter and distinct N-terminus when compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G153962 人 PDE4B (NM_001037340) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 PDE4B (NM_002600) cDNA克隆 transcript variant a
人 PDE4B (NM_001037339) cDNA克隆 transcript variant b
人 PDE4B (NM_001037340) cDNA克隆 transcript variant c
人 PDE4B (NM_001037341) cDNA克隆 transcript variant d

基因简介

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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