人 NOTCH2 (NM_001200001) cDNA克隆

Accession: NM_001200001
基因名称: NOTCH2
基因别名: hN2; AGS2; HJCYS
基因描述: Homo sapiens notch 2 (NOTCH2), transcript variant 2, mRNA.
种属: Human
CDS区长度: 3708 (查看编码区序列)
翻译后氨基酸长度: 1235 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
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G152987 人 NOTCH2 (NM_001200001) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]