人 NACA (NM_001113202) cDNA克隆

基本信息

Accession: NM_001113202
基因名称: NACA
基因别名: HSD48; NACA1
基因描述: Homo sapiens nascent polypeptide-associated complex alpha subunit (NACA), transcript variant 4, mRNA.
种属: Human
CDS区长度: 648 (查看编码区序列)
翻译后氨基酸长度: 215 (查看氨基酸序列)
Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b, which is shorter than isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G152875 人 NACA (NM_001113202) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 NACA (NM_001113203) cDNA克隆 transcript variant 1
人 NACA (NM_001113202) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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