人 MDM2 (NM_001145337) cDNA克隆

基本信息

Accession: NM_001145337
基因名称: MDM2
基因别名: HDMX; hdm2; ACTFS
基因描述: Homo sapiens MDM2 oncogene, E3 ubiquitin protein ligase (MDM2), transcript variant 3, mRNA.
种属: Human
CDS区长度: 1335 (查看编码区序列)
翻译后氨基酸长度: 444 (查看氨基酸序列)
Transcript Variant: This variant (3, also known as P2-MDM2-10) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (g) has a shorter N-terminus and is shorter than isoform a.

订购信息

产品编号 产品名称 载体 规格 价格
G152375 人 MDM2 (NM_001145337) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 MDM2 (NM_002392) cDNA克隆 transcript variant 1
人 MDM2 (NM_001145339) cDNA克隆 transcript variant 2
人 MDM2 (NM_001145337) cDNA克隆 transcript variant 3
人 MDM2 (NM_001145340) cDNA克隆 transcript variant 4
人 MDM2 (NM_001278462) cDNA克隆 transcript variant 5

基因简介

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

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