人 IL4R (NM_000418) cDNA克隆

Accession: NM_000418
基因名称: IL4R
基因别名: CD124; IL4RA; IL-4RA
基因描述: Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1, mRNA.
种属: Human
CDS区长度: 2478 (查看编码区序列)
翻译后氨基酸长度: 825 (查看氨基酸序列)
Transcript Variant: This variant (1) encodes the longest isoform (a).
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G150013 人 IL4R (NM_000418) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]