小鼠 Nfasc (NM_001160318) cDNA克隆

基本信息

Accession: NM_001160318
基因名称: Nfasc
基因别名: NF; AA387016; mKIAA0756; D430023G06Rik
基因描述: Mus musculus neurofascin (Nfasc), transcript variant 4, mRNA.
种属: Mouse
CDS区长度: 3474 (查看编码区序列)
翻译后氨基酸长度: 1157 (查看氨基酸序列)
Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (4) includes the third fibronectin type 3 (FNIII) repeat, lacks the mucin-like domain, and lacks two segments in the N-terminal and central regions, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G144700 小鼠 Nfasc (NM_001160318) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

小鼠 Nfasc (NM_182716) cDNA克隆 transcript variant 1
小鼠 Nfasc (NM_001160316) cDNA克隆 transcript variant 2
小鼠 Nfasc (NM_001160317) cDNA克隆 transcript variant 3
小鼠 Nfasc (NM_001160318) cDNA克隆 transcript variant 4

基因简介

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined. [provided by RefSeq, May 2009]

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