人 GH1 (NM_000515) cDNA克隆

Accession: NM_000515
基因名称: GH1
基因别名: GH; GHN; GH-N; hGH-N; IGHD1B
基因描述: Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.
种属: Human
CDS区长度: 654 (查看编码区序列)
翻译后氨基酸长度: 217 (查看氨基酸序列)
Transcript Variant: This variant (1) utilizes all five exons, generating the predominant 22-kDa isoform (1).
产品编号 产品名称 载体 规格 价格
G144623 人 GH1 (NM_000515) cDNA克隆 pDONR223 2ug质粒 点击询价

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]