人 EIF4G1 (NM_198244) cDNA克隆

基本信息

Accession: NM_198244
基因名称: EIF4G1
基因别名: P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
基因描述: Homo sapiens eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1), transcript variant 3, mRNA.
种属: Human
CDS区长度: 4539 (查看编码区序列)
翻译后氨基酸长度: 1512 (查看氨基酸序列)
Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.

订购信息

产品编号 产品名称 载体 规格 价格
G135835 人 EIF4G1 (NM_198244) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 EIF4G1 (NM_182917) cDNA克隆 transcript variant 1
人 EIF4G1 (NM_198241) cDNA克隆 transcript variant 2
人 EIF4G1 (NM_198244) cDNA克隆 transcript variant 3
人 EIF4G1 (NM_198242) cDNA克隆 transcript variant 4
人 EIF4G1 (NM_004953) cDNA克隆 transcript variant 5
人 EIF4G1 (NM_001194946) cDNA克隆 transcript variant 6
人 EIF4G1 (NM_001194947) cDNA克隆 transcript variant 7

基因简介

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

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