人 EGFR (NM_201284) cDNA克隆

基本信息

Accession: NM_201284
基因名称: EGFR
基因别名: ERBB; HER1; mENA; ERBB1; PIG61
基因描述: Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 4, mRNA.
种属: Human
CDS区长度: 2118 (查看编码区序列)
翻译后氨基酸长度: 705 (查看氨基酸序列)
Transcript Variant: This variant (4) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform d.

订购信息

产品编号 产品名称 载体 规格 价格
G135678 人 EGFR (NM_201284) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 EGFR (NM_005228) cDNA克隆 transcript variant 1
人 EGFR (NM_201282) cDNA克隆 transcript variant 2
人 EGFR (NM_201283) cDNA克隆 transcript variant 3
人 EGFR (NM_201284) cDNA克隆 transcript variant 4

基因简介

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

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