小鼠 Ndufa2 (NM_010885) cDNA克隆

Accession: NM_010885
基因名称: Ndufa2
基因别名: B8; C1-B8; CI-B8; AV000592
基因描述: Mus musculus NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (Ndufa2), mRNA.
种属: Mouse
CDS区长度: 300 (查看编码区序列)
翻译后氨基酸长度: 99 (查看氨基酸序列)
产品编号 产品名称 载体 规格 价格
G134323 小鼠 Ndufa2 (NM_010885) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. The human ortholog of this gene has been characterized, and its structure and redox potential is reported to be similar to that of thioredoxins. It may be involved in regulating complex I activity or assembly via assistance in redox processes. In humans, mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. A pseudogene of this gene is located on chromosome 5. [provided by RefSeq, May 2013]