小鼠 Aspa (NM_023113) cDNA克隆

Accession: NM_023113
基因名称: Aspa
基因别名: Acy2; nur7; Acy-2
基因描述: Mus musculus aspartoacylase (Aspa), mRNA.
种属: Mouse
CDS区长度: 939 (查看编码区序列)
翻译后氨基酸长度: 312 (查看氨基酸序列)
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G128210 小鼠 Aspa (NM_023113) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012]