人 BPNT1 (NM_001286149) cDNA克隆

基本信息

Accession: NM_001286149
基因名称: BPNT1
基因别名: PIP
基因描述: Homo sapiens 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 762 (查看编码区序列)
翻译后氨基酸长度: 253 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4 encode the same isoform (2).

订购信息

产品编号 产品名称 载体 规格 价格
G126714 人 BPNT1 (NM_001286149) cDNA克隆 pDONR223 2ug质粒 点击询价

载体信息

pDONR223载体图谱

相关转录本

人 BPNT1 (NM_006085) cDNA克隆 transcript variant 1
人 BPNT1 (NM_001286149) cDNA克隆 transcript variant 2
人 BPNT1 (NM_001286150) cDNA克隆 transcript variant 3
人 BPNT1 (NM_001286151) cDNA克隆 transcript variant 4

基因简介

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

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