The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
人 PPP1R16B (NM_001172735) cDNA克隆
| Accession: | NM_001172735 |
|---|---|
| 基因名称: | PPP1R16B |
| 基因别名: | TIMAP; ANKRD4 |
| 基因描述: | Homo sapiens protein phosphatase 1, regulatory subunit 16B (PPP1R16B), transcript variant 2, mRNA. |
| 种属: | Human |
| CDS区长度: | 1578 (查看编码区序列) |
| 翻译后氨基酸长度: | 525 (查看氨基酸序列) |
| Transcript Variant: | This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1. |
| 人 PPP1R16B (NM_015568) cDNA克隆 | transcript variant 1 |
| 人 PPP1R16B (NM_001172735) cDNA克隆 | transcript variant 2 |
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