人 PRICKLE1 (NM_001144881) cDNA克隆

Accession: NM_001144881
基因名称: PRICKLE1
基因别名: RILP; EPM1B
基因描述: Homo sapiens prickle homolog 1 (Drosophila) (PRICKLE1), transcript variant 2, mRNA.
种属: Human
CDS区长度: 2496 (查看编码区序列)
翻译后氨基酸长度: 831 (查看氨基酸序列)
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
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G124437 人 PRICKLE1 (NM_001144881) cDNA克隆 pDONR223 2ug质粒 点击询价

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]